The aim of the Priority Programme is to co-design robust, computational, continuum-biomechanical models by developing new methods uniting research in modelling, numerics and a particular medical application. The focus hereby is on models of active biological systems in the human organism to advance methods that can later be integrated within a clinical environment, but rather to define the interfaces between model and clinical application. The Priority Programme does not aim to establish the transfer of the models into the clinic via clinical trials. In particular, the programme will concentrate on coupling strategies for “active” biological systems. The definition of “active” refers to systems that experience a change of state due to physical, chemical, and/or biological phenomena or stimuli. Examples are metabolic processes, growth and remodelling, or electrical stimulation.